Étude CAPSULE COLIQUE - GETAID 2008-2

A PILOT STUDY TO EVALUATE THE APPLICABILITY OF THE CROHN'S DISEASE
ENDOSCOPY INDEX OF SEVERITY TO DATA OBTAINED BY THE COLONIC
CAPSULE ENDOSCOPY IN ILEOCOLONIC CROHN'S DISEASE

Study design

Prospective study, multicenter, open label, non randomized

Inclusion criteria

Active or quiescent Crohn's disease (CD) with indication for ileocolonoscopy.

Main objective

Evaluation of the applicability of the Crohn's Disease Endoscopy Index of Severity (CDEIS) to data obtained by the colon capsule endoscopy (CCE), provided that conventional ileo-colonoscopy and capsule endoscopy lead to comparable overall severity evaluations

Secondary objectives

  1. Reproducibility of the identification of the different anatomic segments on the CCE recordings
  2. Reproducibility of the detection of each elementary lesion and of the evaluation of diseased and ulcerated surfaces in the different segment on the CCE recording
  3. Comparison between the detection of each elementary lesion and the evaluation of diseased and ulcerated surfaces in the different segments at ileocolonoscopy and in the corresponding segments on the CEE recording
  4. Relationship between CDEIS derived from ileocolonoscopy or from CCE recording and clinical activity (Crohn's Disease Activity Index, CDAI) or biological activity (CRP)

Number of patients

24

Screening duration

4 months

Study duration

6 months

Participating centers

3 centers of the GETAID : Lille, Clichy, Nantes